MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response.

Hou, Fajian; Sun, Lijun; Zheng, Hui; Skaug, Brian; Jiang, Qiu-Xing; Chen, Zhijian J

Hou, Fajian; Sun, Lijun; Zheng, Hui; Skaug, Brian; Jiang, Qiu-Xing; Chen, Zhijian J.

Affiliation

Hou F; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

Cell ; 146(3): 448-61, 2011 Aug 05.

Article in En | MEDLINE | ID: mdl-21782231

Subject(s)

Adaptor Proteins, Signal Transducing/metabolism; Immunity, Innate; Adaptor Proteins, Signal Transducing/chemistry; Amino Acid Sequence; Animals; Cell Line; Humans; Interferon Regulatory Factor-3/metabolism; Mice; Mitochondria/metabolism; Mitochondrial Membranes/metabolism; Molecular Sequence Data; Polyubiquitin/metabolism; Prions/metabolism; Protein Structure, Tertiary; Receptors, Retinoic Acid/metabolism; Sendai virus; Signal Transduction; TNF Receptor-Associated Factor 2/metabolism; TNF Receptor-Associated Factor 6/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adaptor Proteins, Signal Transducing / Immunity, Innate Limits: Animals / Humans Language: En Journal: Cell Year: 2011 Type: Article Affiliation country: United States

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