Structure-activity relationship and pharmacokinetic studies of sotrastaurin (AEB071), a promising novel medicine for prevention of graft rejection and treatment of psoriasis.

Wagner, Jürgen; von Matt, Peter; Faller, Bernard; Cooke, Nigel G; Albert, Rainer; Sedrani, Richard; Wiegand, Hansjörg; Jean, Christian; Beerli, Christian; Weckbecker, Gisbert; Evenou, Jean-Pierre; Zenke, Gerhard; Cottens, Sylvain

Wagner, Jürgen; von Matt, Peter; Faller, Bernard; Cooke, Nigel G; Albert, Rainer; Sedrani, Richard; Wiegand, Hansjörg; Jean, Christian; Beerli, Christian; Weckbecker, Gisbert; Evenou, Jean-Pierre; Zenke, Gerhard; Cottens, Sylvain.

Affiliation

Wagner J; Novartis Institutes for BioMedical Research, Basel CH-4002, Switzerland. juergen.wagner@novartis.com

J Med Chem ; 54(17): 6028-39, 2011 Sep 08.

Article in En | MEDLINE | ID: mdl-21797275

Subject(s)

Graft Rejection/prevention & control; Lymphocyte Activation/drug effects; Protein Kinase Inhibitors/therapeutic use; Psoriasis/drug therapy; Pyrroles/therapeutic use; Quinazolines/therapeutic use; Animals; Cells, Cultured; Humans; Macaca fascicularis; Mice; Mice, Inbred BALB C; Protein Kinase C/antagonists & inhibitors; Protein Kinase Inhibitors/chemistry; Protein Kinase Inhibitors/pharmacokinetics; Pyrroles/chemistry; Pyrroles/pharmacokinetics; Quinazolines/chemistry; Quinazolines/pharmacokinetics; Rats; Structure-Activity Relationship; Tissue Distribution

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Psoriasis / Pyrroles / Quinazolines / Lymphocyte Activation / Protein Kinase Inhibitors / Graft Rejection Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2011 Type: Article Affiliation country: Switzerland

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