Development of a semi-automated LC/MS/MS method for the simultaneous quantitation of 14,15-epoxyeicosatrienoic acid, 14,15-dihydroxyeicosatrienoic acid, leukotoxin and leukotoxin diol in human plasma as biomarkers of soluble epoxide hydrolase activity in vivo.

Zhu, Penny; Peck, Brian; Licea-Perez, Hermes; Callahan, James F; Booth-Genthe, Catherine

Zhu, Penny; Peck, Brian; Licea-Perez, Hermes; Callahan, James F; Booth-Genthe, Catherine.

Affiliation

Zhu P; GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, PA 19406, USA. penny.x.zhu@gsk.com

J Chromatogr B Analyt Technol Biomed Life Sci ; 879(25): 2487-93, 2011 Sep 01.

Article in En | MEDLINE | ID: mdl-21798825

Subject(s)

8,11,14-Eicosatrienoic Acid/analogs & derivatives; Epoxide Hydrolases/metabolism; Linoleic Acids/blood; Stearic Acids/blood; 8,11,14-Eicosatrienoic Acid/blood; Biomarkers/blood; Chromatography, Liquid; Epoxide Hydrolases/blood; Female; Humans; Male; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stearic Acids / Linoleic Acids / 8,11,14-Eicosatrienoic Acid / Epoxide Hydrolases Type of study: Diagnostic_studies / Guideline Limits: Female / Humans / Male Language: En Journal: J Chromatogr B Analyt Technol Biomed Life Sci Journal subject: ENGENHARIA BIOMEDICA Year: 2011 Type: Article Affiliation country: United States

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