Discovery of a clinical stage multi-kinase inhibitor sodium (E)-2-{2-methoxy-5-[(2',4',6'-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): synthesis, structure-activity relationship, and biological activity.

Reddy, M V Ramana; Venkatapuram, Padmavathi; Mallireddigari, Muralidhar R; Pallela, Venkat R; Cosenza, Stephen C; Robell, Kimberly A; Akula, Balaiah; Hoffman, Benjamin S; Reddy, E Premkumar

Reddy, M V Ramana; Venkatapuram, Padmavathi; Mallireddigari, Muralidhar R; Pallela, Venkat R; Cosenza, Stephen C; Robell, Kimberly A; Akula, Balaiah; Hoffman, Benjamin S; Reddy, E Premkumar.

Affiliation

Reddy MV; Department of Oncological Sciences, Icahn Medical Institute, Mount Sinai School of Medicine, New York, New York 10029-6514, USA. r.reddy@mssm.edu

J Med Chem ; 54(18): 6254-76, 2011 Sep 22.

Article in En | MEDLINE | ID: mdl-21812421

Subject(s)

Antineoplastic Agents/chemical synthesis; Glycine/analogs & derivatives; Protein Kinase Inhibitors/chemical synthesis; Sulfones/chemical synthesis; Animals; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Apoptosis; Biological Availability; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Glycine/chemical synthesis; Glycine/chemistry; Glycine/pharmacology; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Protein Kinase Inhibitors/chemistry; Protein Kinase Inhibitors/pharmacology; Stereoisomerism; Structure-Activity Relationship; Sulfones/chemistry; Sulfones/pharmacology; Transplantation, Heterologous

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfones / Protein Kinase Inhibitors / Glycine / Antineoplastic Agents Limits: Animals / Female / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2011 Type: Article Affiliation country: United States

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