Amine-constrained pyridazinone histamine H3 receptor antagonists.

Sundar, Babu G; Bailey, Thomas; Bacon, Edward; Aimone, Lisa; Huang, Zeqi; Lyons, Jacquelyn; Raddatz, Rita; Hudkins, Robert

Sundar, Babu G; Bailey, Thomas; Bacon, Edward; Aimone, Lisa; Huang, Zeqi; Lyons, Jacquelyn; Raddatz, Rita; Hudkins, Robert.

Affiliation

Sundar BG; Discovery Research, Cephalon Inc., 145 Brandywine Parkway, West Chester, PA 19380, United States. bsundar@cephalon.com

Bioorg Med Chem Lett ; 21(18): 5543-6, 2011 Sep 15.

Article in En | MEDLINE | ID: mdl-21824776

Subject(s)

Amines/chemistry; Histamine H3 Antagonists/pharmacology; Pyridazines/pharmacology; Animals; Dose-Response Relationship, Drug; Histamine H3 Antagonists/chemical synthesis; Histamine H3 Antagonists/chemistry; Humans; Molecular Structure; Pyridazines/chemical synthesis; Pyridazines/chemistry; Rats; Receptors, Histamine H3/metabolism; Stereoisomerism; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridazines / Histamine H3 Antagonists / Amines Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2011 Type: Article Affiliation country: United States

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