Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase II&#945;.

Lin, Ren-Kuo; Zhou, Nai; Lyu, Yi Lisa; Tsai, Yuan-Chin; Lu, Chang-Hsien; Kerrigan, John; Chen, Yu-tsung; Guan, Ziqiang; Hsieh, Tao-Shih; Liu, Leroy F

Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα.

Lin, Ren-Kuo; Zhou, Nai; Lyu, Yi Lisa; Tsai, Yuan-Chin; Lu, Chang-Hsien; Kerrigan, John; Chen, Yu-tsung; Guan, Ziqiang; Hsieh, Tao-Shih; Liu, Leroy F.

Affiliation

Lin RK; Department of Pharmacology and the Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Jersey 08854, USA.

J Biol Chem ; 286(38): 33591-600, 2011 Sep 23.

Article in En | MEDLINE | ID: mdl-21828038

Subject(s)

Antigens, Neoplasm/metabolism; Apoptosis/drug effects; DNA Topoisomerases, Type II/metabolism; DNA-Binding Proteins/metabolism; Diet; Isothiocyanates/pharmacology; Sulfhydryl Compounds/metabolism; Animals; Cell Line, Transformed; Cell Line, Tumor; Cell Proliferation/drug effects; Cysteine/metabolism; DNA Damage; DNA Fragmentation/drug effects; DNA Topoisomerases, Type II/deficiency; DNA-Binding Proteins/deficiency; Fibroblasts/cytology; Fibroblasts/drug effects; Fibroblasts/enzymology; Gene Knockdown Techniques; Gene Silencing/drug effects; Histones/metabolism; Humans; Mice; Nucleosomes/drug effects; Nucleosomes/metabolism; Poly-ADP-Ribose Binding Proteins; RNA, Small Interfering/metabolism; Signal Transduction/drug effects; ras Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfhydryl Compounds / Apoptosis / Isothiocyanates / DNA Topoisomerases, Type II / Diet / DNA-Binding Proteins / Antigens, Neoplasm Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2011 Type: Article Affiliation country: United States

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