Dopamine dysregulation syndrome after deep brain stimulation of the subthalamic nucleus in Parkinson's disease.
J Neurol Sci
; 312(1-2): 191-3, 2012 Jan 15.
Article
in En
| MEDLINE
| ID: mdl-21872889
ABSTRACT
Dopamine dysregulation syndrome is a complication of the dopaminergic treatment for Parkinson's disease, probably related to sensitization of the mesolimbic dopamine system. The relationship between dopamine dysregulation syndrome and deep brain stimulation of the subthalamic nucleus remains unclear. We report three patients with Parkinson's disease who developed de novo dopamine dysregulation syndrome after deep brain stimulation of the subthalamic nucleus. We hypothesized that the combined effect of dopaminergic replacement therapy and deep brain stimulation on the limbic territory of the subthalamic nucleus could have precipitated the dopamine dysregulation syndrome in these patients, by inducing hyperstimulation of the mesolimbic dopamine system. The outcome of postoperative dopamine dysregulation syndrome is poor despite deep brain stimulation adjustments, attempts to reduce the dose of dopaminergic drugs and the addition of quetiapine or antidepressants.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parkinson Disease
/
Subthalamic Nucleus
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Deep Brain Stimulation
/
Impulsive Behavior
/
Antiparkinson Agents
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Neurol Sci
Year:
2012
Type:
Article
Affiliation country:
Spain