Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.

Viatour, Patrick; Ehmer, Ursula; Saddic, Louis A; Dorrell, Craig; Andersen, Jesper B; Lin, Chenwei; Zmoos, Anne-Flore; Mazur, Pawel K; Schaffer, Bethany E; Ostermeier, Austin; Vogel, Hannes; Sylvester, Karl G; Thorgeirsson, Snorri S; Grompe, Markus; Sage, Julien

Viatour, Patrick; Ehmer, Ursula; Saddic, Louis A; Dorrell, Craig; Andersen, Jesper B; Lin, Chenwei; Zmoos, Anne-Flore; Mazur, Pawel K; Schaffer, Bethany E; Ostermeier, Austin; Vogel, Hannes; Sylvester, Karl G; Thorgeirsson, Snorri S; Grompe, Markus; Sage, Julien.

Affiliation

Viatour P; Department of Genetics, Department of Pediatrics, Stanford University, Stanford, CA, USA; Department of Medical Chemistry, University of Liège, B-4000 Liège, Belgium.

J Exp Med ; 208(10): 1963-76, 2011 Sep 26.

Article in En | MEDLINE | ID: mdl-21875955

Subject(s)

Carcinoma, Hepatocellular/physiopathology; Liver Neoplasms/physiopathology; Receptors, Notch/metabolism; Retinoblastoma Protein/metabolism; Signal Transduction/physiology; Animals; Carcinoma, Hepatocellular/pathology; Cell Line; Cell Proliferation; E2F Transcription Factors/genetics; E2F Transcription Factors/metabolism; Gene Expression Profiling; Humans; Liver Neoplasms/pathology; Mice; Mice, Inbred C57BL; Mice, Knockout; Microarray Analysis; Receptors, Notch/genetics; Retinoblastoma Protein/genetics; Stem Cells/physiology; Transcription, Genetic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Retinoblastoma Protein / Carcinoma, Hepatocellular / Receptors, Notch / Liver Neoplasms Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: J Exp Med Year: 2011 Type: Article Affiliation country: Belgium

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