Enhancing the intestinal membrane permeability of zanamivir: a carrier mediated prodrug approach.

Gupta, Sheeba Varghese; Gupta, Deepak; Sun, Jing; Dahan, Arik; Tsume, Yasuhiro; Hilfinger, John; Lee, Kyung-Dall; Amidon, Gordon L

Gupta, Sheeba Varghese; Gupta, Deepak; Sun, Jing; Dahan, Arik; Tsume, Yasuhiro; Hilfinger, John; Lee, Kyung-Dall; Amidon, Gordon L.

Affiliation

Gupta SV; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109, United States.

Mol Pharm ; 8(6): 2358-67, 2011 Dec 05.

Article in En | MEDLINE | ID: mdl-21905667

Subject(s)

Cell Membrane Permeability/drug effects; Drug Carriers; Intestines/drug effects; Prodrugs/pharmacology; Zanamivir/pharmacokinetics; Animals; Caco-2 Cells; Chromatography, High Pressure Liquid; Drug Carriers/chemistry; Drug Stability; HeLa Cells; Humans; Intestinal Mucosa/metabolism; Molecular Structure; Prodrugs/chemistry; Rats; Zanamivir/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Carriers / Prodrugs / Cell Membrane Permeability / Zanamivir / Intestines Limits: Animals / Humans Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2011 Type: Article Affiliation country: United States

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