Antitrypanosomal activity of fexinidazole, a new oral nitroimidazole drug candidate for treatment of sleeping sickness.

Kaiser, Marcel; Bray, Michael A; Cal, Monica; Bourdin Trunz, Bernadette; Torreele, Els; Brun, Reto

Kaiser, Marcel; Bray, Michael A; Cal, Monica; Bourdin Trunz, Bernadette; Torreele, Els; Brun, Reto.

Affiliation

Kaiser M; Swiss Tropical and Public Health Institute, Parasite Chemotherapy, Socinstrasse 57, CH-4002 Basel, Switzerland. marcel.kaiser@unibas.ch

Antimicrob Agents Chemother ; 55(12): 5602-8, 2011 Dec.

Article in En | MEDLINE | ID: mdl-21911566

Subject(s)

Nitroimidazoles/administration & dosage; Trypanocidal Agents/administration & dosage; Trypanosoma brucei brucei/drug effects; Trypanosoma brucei rhodesiense/drug effects; Trypanosomiasis, African/drug therapy; Animals; Female; Humans; Mice; Nitroimidazoles/pharmacokinetics; Nitroimidazoles/pharmacology; Nitroimidazoles/therapeutic use; Parasitic Sensitivity Tests/methods; Safrole/analogs & derivatives; Safrole/metabolism; Sulfones/metabolism; Treatment Outcome; Trypanocidal Agents/pharmacokinetics; Trypanocidal Agents/pharmacology; Trypanocidal Agents/therapeutic use; Trypanosoma brucei brucei/growth & development; Trypanosoma brucei rhodesiense/growth & development; Trypanosomiasis, African/parasitology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trypanocidal Agents / Trypanosoma brucei brucei / Trypanosomiasis, African / Trypanosoma brucei rhodesiense / Nitroimidazoles Limits: Animals / Female / Humans Language: En Journal: Antimicrob Agents Chemother Year: 2011 Type: Article Affiliation country: Switzerland

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