Cytotoxic pheofungins from an engineered fungus impaired in posttranslational protein modification.
Angew Chem Int Ed Engl
; 50(42): 9843-7, 2011 Oct 10.
Article
in En
| MEDLINE
| ID: mdl-21913294
ABSTRACT
What makes a fungus blush? The deletion of a gene that is required for global protein N-acetylation triggers the production of unprecedented metabolites in Aspergillus nidulans. The pronounced red pigmentation of the engineered mutant is caused by pheofungins (benzothiazinone chromophores), the biogenesis of which is strikingly similar to those of pheomelanins found in red bird feathers and hair of Celtic origin.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aspergillus nidulans
/
Biological Products
/
Fungal Proteins
/
Genetic Engineering
/
Protein Processing, Post-Translational
/
Cytotoxins
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
Angew Chem Int Ed Engl
Year:
2011
Type:
Article
Affiliation country:
Germany