Panax notoginseng saponins inhibit Zymosan A induced atherosclerosis by suppressing integrin expression, FAK activation and NF-&#954;B translocation.

Yuan, Zhongming; Liao, Yu; Tian, Gang; Li, Hua; Jia, Yi; Zhang, Haigang; Tan, Zhenghuai; Li, Xiaohui; Deng, Wenlong; Liu, Kangdong; Zhang, Yiguan

Panax notoginseng saponins inhibit Zymosan A induced atherosclerosis by suppressing integrin expression, FAK activation and NF-κB translocation.

Yuan, Zhongming; Liao, Yu; Tian, Gang; Li, Hua; Jia, Yi; Zhang, Haigang; Tan, Zhenghuai; Li, Xiaohui; Deng, Wenlong; Liu, Kangdong; Zhang, Yiguan.

Affiliation

Yuan Z; Department of Geriatrics, the Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.

J Ethnopharmacol ; 138(1): 150-5, 2011 Oct 31.

Article in En | MEDLINE | ID: mdl-21924337

Subject(s)

Atherosclerosis/prevention & control; Focal Adhesion Kinase 1/metabolism; Integrins/metabolism; NF-kappa B/metabolism; Panax notoginseng/chemistry; Phytotherapy; Saponins/therapeutic use; Animals; Aorta/pathology; Atherosclerosis/metabolism; Atherosclerosis/pathology; Biological Transport/drug effects; Disease Models, Animal; Foam Cells/drug effects; Male; Phosphorylation; Plant Extracts/pharmacology; Plant Extracts/therapeutic use; Plaque, Atherosclerotic/prevention & control; Rats; Rats, Wistar; Saponins/pharmacology; Threonine/metabolism; Zymosan

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Saponins / Integrins / NF-kappa B / Atherosclerosis / Focal Adhesion Kinase 1 / Panax notoginseng / Phytotherapy Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Ethnopharmacol Year: 2011 Type: Article Affiliation country: China

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