Application of new two-sample tests to data from a randomized placebo-controlled heart-failure trial.
Stat Med
; 9(4): 447-56, 1990 Apr.
Article
in En
| MEDLINE
| ID: mdl-2194264
ABSTRACT
In a randomized placebo-controlled double-blind trial of 230 congestive heart failure patients, four treatments were evaluated for efficacy, with exercise tolerance time (ETT) as the primary outcome. Various two-sample tests were applied to the analysis of ETT data. It is shown in this paper that the conventional two-sample tests (t and rank-sum) are insensitive to situations where the effect of the experimental therapy is not consistent across a patient population. Tests recommended by O'Brien are more appropriate for these data. It is also shown that the application of the O'Brien tests led to the identification of sub-groups where the observed effect of the experimental therapy was most pronounced.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Statistics as Topic
/
Heart Failure
Type of study:
Clinical_trials
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Stat Med
Year:
1990
Type:
Article