Parasite infection is associated with Kaposi's sarcoma associated herpesvirus (KSHV) in Ugandan women.
Infect Agent Cancer
; 6(1): 15, 2011 Sep 30.
Article
in En
| MEDLINE
| ID: mdl-21962023
ABSTRACT
BACKGROUND:
Immune modulation by parasites may influence susceptibility to bacteria and viruses. We examined the association between current parasite infections, HIV and syphilis (measured in blood or stool samples using standard methods) and antibodies against Kaposi's sarcoma herpesvirus (KSHV), measured by ELISA, in 1915 stored plasma samples from pregnant women in Entebbe, Uganda.RESULTS:
Seroprevalence of KSHV was higher in women with malaria parasitaemia (73% vs 60% p = 0.01), hookworm (67% vs 56% p = 0.001) and Mansonella perstans (69% vs 59% p = 0.05); seroprevalence increased with increasing intensity of hookworm infection (p < 0.001[trend]). No associations were found for HIV, five other parasites or active syphilis. These effects were not explained by socioeconomic status or education.CONCLUSIONS:
Specific parasite infections are associated with presence of antibodies against KSHV, perhaps mediated via their effect on immune function.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Risk_factors_studies
Language:
En
Journal:
Infect Agent Cancer
Year:
2011
Type:
Article
Affiliation country:
Uganda