In vitro drug treatments reduce the deleterious effects of aggregates containing polyAla expanded PHOX2B proteins.

Di Zanni, Eleonora; Bachetti, Tiziana; Parodi, Sara; Bocca, Paola; Prigione, Ignazia; Di Lascio, Simona; Fornasari, Diego; Ravazzolo, Roberto; Ceccherini, Isabella

Di Zanni, Eleonora; Bachetti, Tiziana; Parodi, Sara; Bocca, Paola; Prigione, Ignazia; Di Lascio, Simona; Fornasari, Diego; Ravazzolo, Roberto; Ceccherini, Isabella.

Affiliation

Di Zanni E; Laboratorio di Genetica Molecolare, Istituto Giannina Gaslini, Largo G. Gaslini 5, 16148 Genova, Italy.

Neurobiol Dis ; 45(1): 508-18, 2012 Jan.

Article in En | MEDLINE | ID: mdl-21964250

Subject(s)

Apoptosis/drug effects; Homeodomain Proteins/genetics; Hypoventilation/congenital; Peptides/genetics; Sleep Apnea, Central/genetics; Transcription Factors/genetics; Animals; Benzoates/pharmacology; Benzoquinones/pharmacology; Biphenyl Compounds/pharmacology; COS Cells; Cells, Cultured; Chlorocebus aethiops; Congo Red/pharmacology; Curcumin/pharmacology; HeLa Cells; Homeodomain Proteins/metabolism; Humans; Hypoventilation/genetics; Hypoventilation/metabolism; Ibuprofen/pharmacology; Lactams, Macrocyclic/pharmacology; Peptides/metabolism; Promoter Regions, Genetic/drug effects; Proteasome Endopeptidase Complex/drug effects; Proteasome Endopeptidase Complex/genetics; Sleep Apnea, Central/metabolism; Transcription Factors/metabolism; Trehalose/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Transcription Factors / Apoptosis / Homeodomain Proteins / Sleep Apnea, Central / Hypoventilation Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2012 Type: Article Affiliation country: Italy

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