Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ.

Sass, Peter; Josten, Michaele; Famulla, Kirsten; Schiffer, Guido; Sahl, Hans-Georg; Hamoen, Leendert; Brötz-Oesterhelt, Heike

Sass, Peter; Josten, Michaele; Famulla, Kirsten; Schiffer, Guido; Sahl, Hans-Georg; Hamoen, Leendert; Brötz-Oesterhelt, Heike.

Affiliation

Sass P; Institute of Medical Microbiology, Immunology, and Parasitology, Pharmaceutical Microbiology Unit, University of Bonn, 53115 Bonn, Germany.

Proc Natl Acad Sci U S A ; 108(42): 17474-9, 2011 Oct 18.

Article in En | MEDLINE | ID: mdl-21969594

Subject(s)

Anti-Bacterial Agents/pharmacology; Bacterial Proteins/metabolism; Cytoskeletal Proteins/metabolism; Endopeptidase Clp/metabolism; Oligopeptides/pharmacology; Anti-Bacterial Agents/chemistry; Bacillus subtilis/cytology; Bacillus subtilis/drug effects; Bacillus subtilis/metabolism; Cell Division/drug effects; Drug Resistance, Bacterial; Enzyme Activation/drug effects; Oligopeptides/chemistry; Staphylococcus aureus/cytology; Staphylococcus aureus/drug effects; Staphylococcus aureus/metabolism; Streptococcus pneumoniae/cytology; Streptococcus pneumoniae/drug effects; Streptococcus pneumoniae/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Bacterial Proteins / Cytoskeletal Proteins / Endopeptidase Clp / Anti-Bacterial Agents Language: En Journal: Proc Natl Acad Sci U S A Year: 2011 Type: Article Affiliation country: Germany

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