Acetaminophen-induced hepatotoxicity and protein nitration in neuronal nitric-oxide synthase knockout mice.

Agarwal, Rakhee; Hennings, Leah; Rafferty, Tonya M; Letzig, Lynda G; McCullough, Sandra; James, Laura P; MacMillan-Crow, Lee Ann; Hinson, Jack A

Agarwal, Rakhee; Hennings, Leah; Rafferty, Tonya M; Letzig, Lynda G; McCullough, Sandra; James, Laura P; MacMillan-Crow, Lee Ann; Hinson, Jack A.

Affiliation

Agarwal R; Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

J Pharmacol Exp Ther ; 340(1): 134-42, 2012 Jan.

Article in En | MEDLINE | ID: mdl-22001257

Subject(s)

Acetaminophen/toxicity; Analgesics, Non-Narcotic/toxicity; Chemical and Drug Induced Liver Injury/enzymology; Nitrates/metabolism; Nitric Oxide Synthase Type I/physiology; Alanine Transaminase/blood; Animals; Aspartate Aminotransferases/blood; Blotting, Western; Chemical and Drug Induced Liver Injury/pathology; Cysteine/metabolism; Cytoplasm/enzymology; Cytoplasm/metabolism; Liver/pathology; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Mitochondria, Liver/drug effects; Mitochondria, Liver/metabolism; Nitric Oxide Synthase Type I/genetics; Oxidative Stress/drug effects; Oxidative Stress/genetics; Superoxide Dismutase/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Analgesics, Non-Narcotic / Nitric Oxide Synthase Type I / Chemical and Drug Induced Liver Injury / Acetaminophen / Nitrates Limits: Animals Language: En Journal: J Pharmacol Exp Ther Year: 2012 Type: Article Affiliation country: United States

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