IL-21 is the primary common Î³ chain-binding cytokine required for human B-cell differentiation in vivo.

Recher, Mike; Berglund, Lucinda J; Avery, Danielle T; Cowan, Morton J; Gennery, Andrew R; Smart, Joanne; Peake, Jane; Wong, Melanie; Pai, Sung-Yun; Baxi, Sachin; Walter, Jolan E; Palendira, Umaimainthan; Tangye, Gillian A; Rice, Michael; Brothers, Shannon; Al-Herz, Waleed; Oettgen, Hans; Eibel, Hermann; Puck, Jennifer M; Cattaneo, Federica; Ziegler, John B; Giliani, Silvia; Tangye, Stuart G; Notarangelo, Luigi D

Recher, Mike; Berglund, Lucinda J; Avery, Danielle T; Cowan, Morton J; Gennery, Andrew R; Smart, Joanne; Peake, Jane; Wong, Melanie; Pai, Sung-Yun; Baxi, Sachin; Walter, Jolan E; Palendira, Umaimainthan; Tangye, Gillian A; Rice, Michael; Brothers, Shannon; Al-Herz, Waleed; Oettgen, Hans; Eibel, Hermann; Puck, Jennifer M; Cattaneo, Federica; Ziegler, John B; Giliani, Silvia; Tangye, Stuart G; Notarangelo, Luigi D.

Affiliation

Recher M; Division of Immunology, Children's Hospital, Harvard Medical School, Boston, MA, USA.

Blood ; 118(26): 6824-35, 2011 Dec 22.

Article in En | MEDLINE | ID: mdl-22039266

Subject(s)

B-Lymphocytes/immunology; Cell Differentiation/immunology; Interleukin Receptor Common gamma Subunit/immunology; Interleukins/immunology; B-Lymphocytes/metabolism; CD40 Ligand/immunology; CD40 Ligand/metabolism; Cells, Cultured; Flow Cytometry; Hematopoietic Stem Cell Transplantation; Humans; Immunoglobulin A/blood; Immunoglobulin A/immunology; Immunoglobulin M/blood; Immunoglobulin M/immunology; Immunologic Memory/immunology; Interleukin Receptor Common gamma Subunit/genetics; Interleukin Receptor Common gamma Subunit/metabolism; Interleukins/metabolism; Janus Kinase 3/genetics; Janus Kinase 3/immunology; Janus Kinase 3/metabolism; Mutation; Protein Binding; Severe Combined Immunodeficiency/genetics; Severe Combined Immunodeficiency/immunology; Severe Combined Immunodeficiency/metabolism; X-Linked Combined Immunodeficiency Diseases/genetics; X-Linked Combined Immunodeficiency Diseases/immunology; X-Linked Combined Immunodeficiency Diseases/metabolism

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: B-Lymphocytes / Cell Differentiation / Interleukins / Interleukin Receptor Common gamma Subunit Type of study: Prognostic_studies Limits: Humans Language: En Journal: Blood Year: 2011 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google