Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin.

Dagälv, Anders; Holmborn, Katarina; Kjellén, Lena; Abrink, Magnus

Dagälv, Anders; Holmborn, Katarina; Kjellén, Lena; Abrink, Magnus.

Affiliation

Dagälv A; Department of Medical Biochemistry and Microbiology, Uppsala University, and Biomedical Sciences and Veterinary Public Health, SLU, SE-751 23 Uppsala, Sweden.

J Biol Chem ; 286(52): 44433-40, 2011 Dec 30.

Article in En | MEDLINE | ID: mdl-22049073

Subject(s)

Heparin/biosynthesis; Heparitin Sulfate/biosynthesis; Mast Cells/metabolism; Models, Biological; Sulfotransferases/metabolism; Amidohydrolases/genetics; Amidohydrolases/metabolism; Animals; Cells, Cultured; Embryo, Mammalian/cytology; Embryo, Mammalian/metabolism; Embryonic Stem Cells/cytology; Embryonic Stem Cells/metabolism; Golgi Apparatus/enzymology; Golgi Apparatus/genetics; Heparin/genetics; Heparitin Sulfate/genetics; Mast Cells/cytology; Mice; Mice, Knockout; Peptide Hydrolases/metabolism; Sulfotransferases/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Heparin / Sulfotransferases / Heparitin Sulfate / Mast Cells / Models, Biological Limits: Animals Language: En Journal: J Biol Chem Year: 2011 Type: Article Affiliation country: Sweden

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