Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is phosphatidylinositol 3-kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent.

Isfort, Katrin; Ebert, Franziska; Bornhorst, Julia; Sargin, Sarah; Kardakaris, Rozina; Pasparakis, Manolis; Bähler, Martin; Schwerdtle, Tanja; Schwab, Albrecht; Hanley, Peter J

Isfort, Katrin; Ebert, Franziska; Bornhorst, Julia; Sargin, Sarah; Kardakaris, Rozina; Pasparakis, Manolis; Bähler, Martin; Schwerdtle, Tanja; Schwab, Albrecht; Hanley, Peter J.

Affiliation

Isfort K; Institut für Physiologie II, Westfälische Wilhelms-Universität Münster, 48149 Münster, Germany.

J Biol Chem ; 286(52): 44776-87, 2011 Dec 30.

Article in En | MEDLINE | ID: mdl-22057273

Subject(s)

Adenosine Triphosphate/immunology; Chemotaxis/physiology; Complement C5a/immunology; Macrophages, Peritoneal/immunology; Phosphatidylinositol 3-Kinases/immunology; Purinergic P2Y Receptor Agonists/immunology; Receptors, Purinergic P2Y12/immunology; Receptors, Purinergic P2Y2/immunology; p38 Mitogen-Activated Protein Kinases/immunology; Adenosine Diphosphate/genetics; Adenosine Diphosphate/immunology; Adenosine Diphosphate/metabolism; Adenosine Diphosphate/pharmacology; Adenosine Triphosphate/analogs & derivatives; Adenosine Triphosphate/metabolism; Adenosine Triphosphate/pharmacology; Animals; Autocrine Communication/drug effects; Autocrine Communication/physiology; Chemotaxis/drug effects; Complement C5a/genetics; Complement C5a/metabolism; Macrophages, Peritoneal/metabolism; Mice; Mice, Knockout; Paracrine Communication/drug effects; Paracrine Communication/physiology; Phosphatidylinositol 3-Kinases/genetics; Phosphatidylinositol 3-Kinases/metabolism; Pseudopodia/genetics; Pseudopodia/immunology; Pseudopodia/metabolism; Purinergic P2Y Receptor Agonists/metabolism; Purinergic P2Y Receptor Agonists/pharmacology; Receptors, Purinergic P2Y12/genetics; Receptors, Purinergic P2Y12/metabolism; Receptors, Purinergic P2Y2/genetics; Receptors, Purinergic P2Y2/metabolism; p38 Mitogen-Activated Protein Kinases/genetics; p38 Mitogen-Activated Protein Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Complement C5a / Adenosine Triphosphate / Chemotaxis / Macrophages, Peritoneal / Phosphatidylinositol 3-Kinases / P38 Mitogen-Activated Protein Kinases / Receptors, Purinergic P2Y2 / Receptors, Purinergic P2Y12 / Purinergic P2Y Receptor Agonists Language: En Journal: J Biol Chem Year: 2011 Type: Article Affiliation country: Germany

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