Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH.

Lo Surdo, Paola; Bottomley, Matthew J; Calzetta, Alessandra; Settembre, Ethan C; Cirillo, Agostino; Pandit, Shilpa; Ni, Yan G; Hubbard, Brian; Sitlani, Ayesha; Carfí, Andrea

Lo Surdo, Paola; Bottomley, Matthew J; Calzetta, Alessandra; Settembre, Ethan C; Cirillo, Agostino; Pandit, Shilpa; Ni, Yan G; Hubbard, Brian; Sitlani, Ayesha; Carfí, Andrea.

Affiliation

Lo Surdo P; Department of Biochemistry and Molecular Biology, IRBM P. Angeletti, Via Pontina Km 30.600, Pomezia, Rome I-00040, Italy.

EMBO Rep ; 12(12): 1300-5, 2011 Dec 01.

Article in En | MEDLINE | ID: mdl-22081141

Subject(s)

Proprotein Convertases/chemistry; Receptors, LDL/chemistry; Receptors, LDL/metabolism; Serine Endopeptidases/chemistry; Down-Regulation; Humans; Hydrogen-Ion Concentration; Models, Molecular; Proprotein Convertase 9; Proprotein Convertases/metabolism; Protein Binding; Protein Structure, Tertiary; Proteolysis; Serine Endopeptidases/metabolism; Surface Plasmon Resonance

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, LDL / Serine Endopeptidases / Proprotein Convertases Type of study: Prognostic_studies Limits: Humans Language: En Journal: EMBO Rep Journal subject: BIOLOGIA MOLECULAR Year: 2011 Type: Article Affiliation country: Italy

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