Influences on blockade by t-butylbicyclo-phosphoro-thionate of GABA(A) receptor spontaneous gating, agonist activation and desensitization.

Othman, Nidaa A; Gallacher, Michael; Deeb, Tarek Z; Baptista-Hon, Daniel T; Perry, David C; Hales, Tim G

Othman, Nidaa A; Gallacher, Michael; Deeb, Tarek Z; Baptista-Hon, Daniel T; Perry, David C; Hales, Tim G.

Affiliation

Othman NA; The Institute of Academic Anaesthesia, Division of Neuroscience, University of Dundee, Dundee DD1 9SY, UK.

J Physiol ; 590(1): 163-78, 2012 Jan 01.

Article in En | MEDLINE | ID: mdl-22083597

Subject(s)

Bridged Bicyclo Compounds, Heterocyclic/pharmacology; GABA-A Receptor Antagonists/pharmacology; Ion Channel Gating/drug effects; Receptors, GABA-A/metabolism; Bicuculline/pharmacology; Binding Sites; Cell Line; Glycine/metabolism; HEK293 Cells; Humans; Mutation; Patch-Clamp Techniques/methods; Picrotoxin/pharmacology; Receptors, Serotonin, 5-HT3/metabolism; gamma-Aminobutyric Acid/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ion Channel Gating / Receptors, GABA-A / Bridged Bicyclo Compounds, Heterocyclic / GABA-A Receptor Antagonists Limits: Humans Language: En Journal: J Physiol Year: 2012 Type: Article Affiliation country: United kingdom

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