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A clinical study to assess CYP1A2 and CYP3A4 induction by AZD7325, a selective GABA(A) receptor modulator - an in vitro and in vivo comparison.
Zhou, Diansong; Sunzel, Maria; Ribadeneira, Maria D; Smith, Mark A; Desai, Dhaval; Lin, Jianrong; Grimm, Scott W.
Affiliation
  • Zhou D; Clinical Pharmacology Science DMPK Clinical Neuroscience, AstraZeneca Pharmaceuticals LP, Wilmington, DE 19850, USA. diansong.zhou@astrazeneca.com
Br J Clin Pharmacol ; 74(1): 98-108, 2012 Jul.
Article in En | MEDLINE | ID: mdl-22122233
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, GABA-A / GABA Modulators / Cytochrome P-450 CYP1A2 / Hepatocytes / Cytochrome P-450 CYP3A / Heterocyclic Compounds, 2-Ring Type of study: Prognostic_studies Limits: Adolescent / Adult / Humans / Male / Middle aged Language: En Journal: Br J Clin Pharmacol Year: 2012 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, GABA-A / GABA Modulators / Cytochrome P-450 CYP1A2 / Hepatocytes / Cytochrome P-450 CYP3A / Heterocyclic Compounds, 2-Ring Type of study: Prognostic_studies Limits: Adolescent / Adult / Humans / Male / Middle aged Language: En Journal: Br J Clin Pharmacol Year: 2012 Type: Article Affiliation country: United States