NADPH oxidase-dependent and -independent mechanisms of reported inhibitors of reactive oxygen generation.

Gatto, Gregory J; Ao, Zhaohui; Kearse, Michael G; Zhou, Mei; Morales, Cyndi R; Daniels, Erin; Bradley, Benjamin T; Goserud, Matthew T; Goodman, Krista B; Douglas, Stephen A; Harpel, Mark R; Johns, Douglas G

Gatto, Gregory J; Ao, Zhaohui; Kearse, Michael G; Zhou, Mei; Morales, Cyndi R; Daniels, Erin; Bradley, Benjamin T; Goserud, Matthew T; Goodman, Krista B; Douglas, Stephen A; Harpel, Mark R; Johns, Douglas G.

Affiliation

Gatto GJ; Metabolic Pathways and Cardiovascular Therapeutic Area Unit, GlaxoSmithKline Pharmaceuticals, King of Prussia, PA 19406, USA. greg.j.gatto@gsk.com

J Enzyme Inhib Med Chem ; 28(1): 95-104, 2013 Feb.

Article in En | MEDLINE | ID: mdl-22136506

Subject(s)

Enzyme Inhibitors/pharmacology; Membrane Glycoproteins/antagonists & inhibitors; NADPH Oxidases/antagonists & inhibitors; Reactive Oxygen Species/metabolism; Base Sequence; Benzoxazoles/pharmacology; Cardiovascular Agents/pharmacology; Cells, Cultured; Humans; Membrane Glycoproteins/genetics; Membrane Glycoproteins/metabolism; Molecular Sequence Data; NADPH Oxidase 2; NADPH Oxidases/genetics; NADPH Oxidases/metabolism; Neutrophils/drug effects; Neutrophils/enzymology; Neutrophils/metabolism; Perhexiline/pharmacology; Protein Kinase C/antagonists & inhibitors; Protein Kinase C beta; Reactive Oxygen Species/antagonists & inhibitors; Suramin/pharmacology; Triazoles/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Reactive Oxygen Species / NADPH Oxidases / Enzyme Inhibitors Limits: Humans Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2013 Type: Article Affiliation country: United States

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