Glycine insertion at protease cleavage site of SNAP25 resists cleavage but enhances affinity for botulinum neurotoxin serotype A.

Ho, Mengfei; Goh, Cheong-Hian; Brothers, Michael C; Wang, Shihua; Young, Ryan L; Ou, Yuxiang; Lui, Juliana Nga-Man; Kalafatis, Marinos; Lan, Xiuwan; Wolf, Abigail E; Rienstra, Chad M; Wilson, Brenda A

Ho, Mengfei; Goh, Cheong-Hian; Brothers, Michael C; Wang, Shihua; Young, Ryan L; Ou, Yuxiang; Lui, Juliana Nga-Man; Kalafatis, Marinos; Lan, Xiuwan; Wolf, Abigail E; Rienstra, Chad M; Wilson, Brenda A.

Affiliation

Ho M; Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.

Protein Sci ; 21(3): 318-26, 2012 Mar.

Article in En | MEDLINE | ID: mdl-22170566

Subject(s)

Botulinum Toxins, Type A/chemistry; Botulinum Toxins, Type A/metabolism; Glycine/chemistry; Synaptosomal-Associated Protein 25/chemistry; Binding Sites/physiology; Catalytic Domain; Models, Molecular; Synaptosomal-Associated Protein 25/antagonists & inhibitors; Synaptosomal-Associated Protein 25/genetics; Synaptosomal-Associated Protein 25/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Botulinum Toxins, Type A / Synaptosomal-Associated Protein 25 / Glycine Type of study: Prognostic_studies Language: En Journal: Protein Sci Journal subject: BIOQUIMICA Year: 2012 Type: Article Affiliation country: United States

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