[Effect of parasympathectomy on the salivary secretion of submandibular gland in rats].
Zhonghua Kou Qiang Yi Xue Za Zhi
; 46(9): 519-23, 2011 Sep.
Article
in Zh
| MEDLINE
| ID: mdl-22177352
ABSTRACT
OBJECTIVE:
To investigate the effect of parasympathectomy on secretion of submandibular glands and the feasibility of treatment for xerostomia in rats.METHODS:
Twenty Sprague-Dawley male rats weighing 200 - 300 g were randomly divided into the experimental group (n = 12), in which the right chorda-lingual nerve was cut, and the control group (n = 8). The secretion of submandibular gland was measured for 5 min by Schirmer test for both groups.RESULTS:
The stimulated saliva flow rate decreased on 1st, 12th and 24th week after denervation in the right operated submandibular glands (P < 0.05). No difference in secretion was found between the left non-operated glands and the control group. Comparing with the left non-operated gland and the control gland, the saliva flow rate at rest in the right operated submandibular gland increased on the 1st, 12th and 24th week (P < 0.05).CONCLUSIONS:
After parasympathectomy of rat submandibular glands, the saliva flow rate at rest increased in the denervated gland, which suggests that parasympathectomy of submandibular gland might be used as a therapy for xerostomia.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Saliva
/
Submandibular Gland
/
Parasympathectomy
Limits:
Animals
Language:
Zh
Journal:
Zhonghua Kou Qiang Yi Xue Za Zhi
Journal subject:
ODONTOLOGIA
Year:
2011
Type:
Article
Affiliation country:
China