Clinical utility of ¹8F FDG-PET/CT in the detection of bone marrow disease in Hodgkin's lymphoma.
Br J Radiol
; 85(1016): e490-6, 2012 Aug.
Article
in En
| MEDLINE
| ID: mdl-22215887
ABSTRACT
OBJECTIVE:
The aim of the study was to evaluate the potential role of fludeoxyglucose (FDG)-positron emission tomography (PET)/CT in the detection of bone/bone marrow disease in patients with Hodgkin's lymphoma (HL).METHODS:
We retrospectively reviewed ((18)F)-FDG-PET/CT scans of 122 newly diagnosed, biopsy-proven cases of HL performed between November 2009 and June 2010. All the patients were staged before treatment by both PET/CT and bone marrow biopsy (BMB). Patients were subdivided into three groups based on the findings of FDG-PET/CT. Group A consisted of patients showing diffuse FDG uptake, Group B consisted of patients showing unifocal FDG uptake and Group C patients showed multifocal FDG-avid foci on PET/CT scans. Bone marrow results were also reviewed and considered positive if lymphomatous involvement was detected on bone marrow trephine biopsy. BMB results were correlated with FDG-PET/CT findings.RESULTS:
There were 122 patients in total-81 (66.4%) were male and 41 (33.6%) were female. The age range was from 6 years to 78 years (mean 35.70 years). PET/CT was reported as negative for bone/bone marrow involvement in 85 (69.7%) patients, while the remaining 37 showed abnormal FDG uptake. The sensitivity of FDG-PET/CT was calculated to be 100%, the specificity was 76.57%, the negative predictive value was 76.57%, the positive predictive value was 29.72% and the diagnostic accuracy was 78.62%.CONCLUSION:
(18)F-FDG-PET/CT and BMB are complementary in the evaluation of bone marrow disease.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hodgkin Disease
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Tomography, X-Ray Computed
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Bone Marrow Neoplasms
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Radiopharmaceuticals
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Fluorodeoxyglucose F18
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Positron-Emission Tomography
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Multimodal Imaging
Type of study:
Diagnostic_studies
/
Evaluation_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
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Aged
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Child
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Female
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Humans
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Male
/
Middle aged
Language:
En
Journal:
Br J Radiol
Year:
2012
Type:
Article
Affiliation country:
Pakistan