Enteropathy-associated T-cell lymphoma complicating an autoimmune enteropathy.
Gastroenterology
; 142(4): 726-729.e3; quiz e13-4, 2012 Apr.
Article
in En
| MEDLINE
| ID: mdl-22226659
ABSTRACT
Enteropathy-associated T-cell lymphoma (EATL) is a rare non-Hodgkin lymphoma frequently associated with celiac disease. We report a case of EATL complicating adult autoimmune enteropathy (AIE). Analysis of phenotype, rearrangements in T-cell receptor genes, and chromosome alterations by high-resolution comparative genomic hybridization identified features distinct from those described for types I and II EATL. Furthermore, EATL arose from a single T-cell clone that had been present for several years in AIE-associated, oligoclonal, intestinal T-cell infiltrate. Emerging T-cell clones should be monitored in patients with AIE who receive long-term immunosuppressive therapy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polyendocrinopathies, Autoimmune
/
Genes, T-Cell Receptor
/
Enteropathy-Associated T-Cell Lymphoma
/
Intestinal Neoplasms
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Gastroenterology
Year:
2012
Type:
Article
Affiliation country:
France