Premarital hemoglobinopathy screening in Kayseri: a city in Middle Anatolia region of Turkey.
J Pediatr Hematol Oncol
; 34(2): e49-52, 2012 Mar.
Article
in En
| MEDLINE
| ID: mdl-22246155
ABSTRACT
OBJECTIVE:
The aim of the present study was to report the frequency of ß-thalassemia trait and other hemoglobinopathies in Kayseri province, which is located in Middle Anatolia of Turkey, as part of the premarital screening program.METHODS:
The study included subjects admitted to Family Planning Center for premarital screening test between January 2009 and March 2010. Blood samples of the couples were obtained during admission to the marriage office. Complete blood counts and hemoglobin (Hb) variant analysis were performed with automatic counter and capillary electrophoresis.RESULTS:
A total of 10,261 people were screened. The prevalence of patients with the ß-thalassemia trait was 1.71% (175/10261). Moreover, HbD Punjab and HbO Arab were the most common Hb variants after ß-thalassemia trait with the frequencies of 0.36% and 0.09%, respectively. Only 2 HbS were detected in 15 months of screening time. In 2 couples both partners were found to be carriers of ß-thalassemia trait, and both partners of 1 couple to be carrier of HbD.CONCLUSIONS:
Kayseri is not a high-risk region according to Mediterranean parts of Turkey, but the city takes migrations apart from neighbor cities, migrations from East and South provinces because of its geographic and industrial situation. For that reason detecting carrier couples with premarital screening program is an effective way of controlling thalassemia major.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Premarital Examinations
/
Mass Screening
/
Beta-Thalassemia
Type of study:
Diagnostic_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
J Pediatr Hematol Oncol
Journal subject:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Year:
2012
Type:
Article
Affiliation country:
Turkey