ORFV: a novel oncolytic and immune stimulating parapoxvirus therapeutic.

Rintoul, Julia L; Lemay, Chantal G; Tai, Lee-Hwa; Stanford, Marianne M; Falls, Theresa J; de Souza, Christiano T; Bridle, Byram W; Daneshmand, Manijeh; Ohashi, Pamela S; Wan, Yonghong; Lichty, Brian D; Mercer, Andrew A; Auer, Rebecca C; Atkins, Harold L; Bell, John C

Rintoul, Julia L; Lemay, Chantal G; Tai, Lee-Hwa; Stanford, Marianne M; Falls, Theresa J; de Souza, Christiano T; Bridle, Byram W; Daneshmand, Manijeh; Ohashi, Pamela S; Wan, Yonghong; Lichty, Brian D; Mercer, Andrew A; Auer, Rebecca C; Atkins, Harold L; Bell, John C.

Affiliation

Rintoul JL; Department of Biochemistry, Microbiology & Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Canada.

Mol Ther ; 20(6): 1148-57, 2012 Jun.

Article in En | MEDLINE | ID: mdl-22273579

Subject(s)

Genetic Vectors/administration & dosage; Neoplasms/immunology; Neoplasms/therapy; Oncolytic Virotherapy; Oncolytic Viruses/immunology; Orf virus/immunology; Animals; Cell Line, Tumor; Cytokines/immunology; Cytokines/metabolism; Disease Models, Animal; Female; Genetic Therapy; Genetic Vectors/adverse effects; Humans; Immunity, Innate; Killer Cells, Natural/immunology; Lung/immunology; Lung/metabolism; Lung Neoplasms/secondary; Melanoma, Experimental/genetics; Melanoma, Experimental/immunology; Melanoma, Experimental/therapy; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasms/genetics; Oncolytic Viruses/genetics; Orf virus/genetics; Spleen/immunology; Spleen/metabolism; Tumor Burden; Virus Replication; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Orf virus / Oncolytic Viruses / Oncolytic Virotherapy / Genetic Vectors / Neoplasms Limits: Animals / Female / Humans Language: En Journal: Mol Ther Journal subject: BIOLOGIA MOLECULAR / TERAPEUTICA Year: 2012 Type: Article Affiliation country: Canada

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