A caveolae-targeted L-type Ca²+ channel antagonist inhibits hypertrophic signaling without reducing cardiac contractility.

Makarewich, Catherine A; Correll, Robert N; Gao, Hui; Zhang, Hongyu; Yang, Baohua; Berretta, Remus M; Rizzo, Victor; Molkentin, Jeffery D; Houser, Steven R

Makarewich, Catherine A; Correll, Robert N; Gao, Hui; Zhang, Hongyu; Yang, Baohua; Berretta, Remus M; Rizzo, Victor; Molkentin, Jeffery D; Houser, Steven R.

Affiliation

Makarewich CA; Cardiovascular Research Center and Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA.

Circ Res ; 110(5): 669-74, 2012 Mar 02.

Article in En | MEDLINE | ID: mdl-22302787

Subject(s)

Calcium Channel Blockers/pharmacology; Calcium Channels, L-Type/drug effects; Cardiomyopathy, Hypertrophic/physiopathology; Caveolae/drug effects; Myocardial Contraction/drug effects; Signal Transduction/drug effects; Animals; Calcium/metabolism; Calcium Channels, L-Type/metabolism; Cardiomyopathy, Hypertrophic/pathology; Cats; Caveolae/metabolism; Caveolin 3/metabolism; Cell Nucleus/metabolism; Cells, Cultured; Disease Models, Animal; Myocardial Contraction/physiology; Myocytes, Cardiac/drug effects; Myocytes, Cardiac/metabolism; Myocytes, Cardiac/pathology; NFATC Transcription Factors/metabolism; Receptors, Adrenergic, beta-2/drug effects; Signal Transduction/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiomyopathy, Hypertrophic / Calcium Channel Blockers / Signal Transduction / Calcium Channels, L-Type / Caveolae / Myocardial Contraction Type of study: Prognostic_studies Limits: Animals Language: En Journal: Circ Res Year: 2012 Type: Article Affiliation country: United States

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