The growth response to androgen receptor signaling in ER&#945;-negative human breast cells is dependent on p21 and mediated by MAPK activation.

Garay, Joseph P; Karakas, Bedri; Abukhdeir, Abde M; Cosgrove, David P; Gustin, John P; Higgins, Michaela J; Konishi, Hiroyuki; Konishi, Yuko; Lauring, Josh; Mohseni, Morassa; Wang, Grace M; Jelovac, Danijela; Weeraratna, Ashani; Sherman Baust, Cheryl A; Morin, Patrice J; Toubaji, Antoun; Meeker, Alan; De Marzo, Angelo M; Lewis, Gloria; Subhawong, Andrea; Argani, Pedram; Park, Ben H

The growth response to androgen receptor signaling in ERα-negative human breast cells is dependent on p21 and mediated by MAPK activation.

Garay, Joseph P; Karakas, Bedri; Abukhdeir, Abde M; Cosgrove, David P; Gustin, John P; Higgins, Michaela J; Konishi, Hiroyuki; Konishi, Yuko; Lauring, Josh; Mohseni, Morassa; Wang, Grace M; Jelovac, Danijela; Weeraratna, Ashani; Sherman Baust, Cheryl A; Morin, Patrice J; Toubaji, Antoun; Meeker, Alan; De Marzo, Angelo M; Lewis, Gloria; Subhawong, Andrea; Argani, Pedram; Park, Ben H.

Affiliation

Garay JP; The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. bpark2@jhmi.edu

Breast Cancer Res ; 14(1): R27, 2012 Feb 09.

Article in En | MEDLINE | ID: mdl-22321971

Subject(s)

Cyclin-Dependent Kinase Inhibitor p21/metabolism; MAP Kinase Signaling System; Receptors, Androgen/physiology; Androgen Antagonists/pharmacology; Androgens/pharmacology; Anilides/pharmacology; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclin D1/metabolism; Cyclin-Dependent Kinase Inhibitor p21/genetics; Enzyme Activation; Epithelial Cells/drug effects; Epithelial Cells/metabolism; Epithelial Cells/physiology; Estrogen Receptor alpha/metabolism; Extracellular Signal-Regulated MAP Kinases/metabolism; Female; Gene Expression; Humans; Metribolone/pharmacology; Nitriles/pharmacology; Receptors, Androgen/biosynthesis; Receptors, Androgen/genetics; Recombinant Proteins/biosynthesis; Recombinant Proteins/genetics; Tosyl Compounds/pharmacology; Up-Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Androgen / MAP Kinase Signaling System / Cyclin-Dependent Kinase Inhibitor p21 Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: Breast Cancer Res Journal subject: NEOPLASIAS Year: 2012 Type: Article Affiliation country: United States

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