Laminin-111 protein therapy reduces muscle pathology and improves viability of a mouse model of merosin-deficient congenital muscular dystrophy.

Rooney, Jachinta E; Knapp, Jolie R; Hodges, Bradley L; Wuebbles, Ryan D; Burkin, Dean J

Rooney, Jachinta E; Knapp, Jolie R; Hodges, Bradley L; Wuebbles, Ryan D; Burkin, Dean J.

Affiliation

Rooney JE; Department of Pharmacology, Center for Molecular Medicine, University of Nevada School of Medicine, Reno, Nevada 89557, USA.

Am J Pathol ; 180(4): 1593-602, 2012 Apr.

Article in En | MEDLINE | ID: mdl-22322301

Subject(s)

Laminin/therapeutic use; Muscular Dystrophies/drug therapy; Animals; Apoptosis/drug effects; Cell Line; Disease Models, Animal; Drug Evaluation, Preclinical/methods; Female; Fibrosis; Humans; Injections, Intramuscular; Injections, Intraperitoneal; Kaplan-Meier Estimate; Laminin/administration & dosage; Laminin/deficiency; Laminin/metabolism; Mice; Motor Activity/drug effects; Muscle Strength/drug effects; Muscle, Skeletal/metabolism; Muscle, Skeletal/pathology; Muscle, Skeletal/physiopathology; Muscular Dystrophies/metabolism; Muscular Dystrophies/pathology; Muscular Dystrophies/physiopathology; Myoblasts/drug effects; Myoblasts/pathology; Myositis/prevention & control; Protein Isoforms/administration & dosage; Protein Isoforms/therapeutic use; Weight Loss/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Laminin / Muscular Dystrophies Limits: Animals / Female / Humans Language: En Journal: Am J Pathol Year: 2012 Type: Article Affiliation country: United States

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