Expanded ATXN3 frameshifting events are toxic in Drosophila and mammalian neuron models.

Stochmanski, Shawn J; Therrien, Martine; Laganière, Janet; Rochefort, Daniel; Laurent, Sandra; Karemera, Liliane; Gaudet, Rebecca; Vyboh, Kishanda; Van Meyel, Don J; Di Cristo, Graziella; Dion, Patrick A; Gaspar, Claudia; Rouleau, Guy A

Stochmanski, Shawn J; Therrien, Martine; Laganière, Janet; Rochefort, Daniel; Laurent, Sandra; Karemera, Liliane; Gaudet, Rebecca; Vyboh, Kishanda; Van Meyel, Don J; Di Cristo, Graziella; Dion, Patrick A; Gaspar, Claudia; Rouleau, Guy A.

Affiliation

Stochmanski SJ; Center of Excellence in Neuroscience of the Université de Montréal (CENUM), Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.

Hum Mol Genet ; 21(10): 2211-8, 2012 May 15.

Article in En | MEDLINE | ID: mdl-22337953

Subject(s)

Drosophila/genetics; Frameshifting, Ribosomal; Nerve Tissue Proteins/genetics; Neurons/metabolism; Nuclear Proteins/genetics; Transcription Factors/genetics; Animals; Animals, Genetically Modified; Ataxin-3; Drosophila/metabolism; Immunohistochemistry; Machado-Joseph Disease/genetics; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins/metabolism; Nuclear Proteins/metabolism; Peptides/chemistry; RNA, Messenger/metabolism; Transcription Factors/metabolism; Transfection; Trinucleotide Repeat Expansion

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Nuclear Proteins / Frameshifting, Ribosomal / Drosophila / Nerve Tissue Proteins / Neurons Type of study: Prognostic_studies Limits: Animals Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2012 Type: Article Affiliation country: Canada

Fulltext

XML

PubMed Links

Search on Google