Synthesis and evaluation of a new series of 1'-cyclobutyl-6-(4-piperidyloxy)spiro[benzopyran-2,4'-piperidine] derivatives as high affinity and selective histamine-3 receptor (H3R) antagonists.

Dandu, Reddeppa Reddy; Lyons, Jacquelyn A; Raddatz, Rita; Huang, Zeqi; Aimone, Lisa D; Hudkins, Robert L

Dandu, Reddeppa Reddy; Lyons, Jacquelyn A; Raddatz, Rita; Huang, Zeqi; Aimone, Lisa D; Hudkins, Robert L.

Affiliation

Dandu RR; Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380, USA. rdandu1321@gmail.com

Bioorg Med Chem Lett ; 22(6): 2151-3, 2012 Mar 15.

Article in En | MEDLINE | ID: mdl-22365751

Subject(s)

Benzopyrans/chemical synthesis; Histamine Antagonists/chemical synthesis; Piperidines/chemical synthesis; Receptors, Histamine H3/metabolism; Spiro Compounds/chemical synthesis; Administration, Oral; Animals; Benzopyrans/pharmacokinetics; Benzopyrans/pharmacology; Cytochrome P-450 Enzyme System/metabolism; Histamine Antagonists/pharmacokinetics; Histamine Antagonists/pharmacology; Humans; Injections, Intravenous; Microsomes, Liver/drug effects; Microsomes, Liver/metabolism; Piperidines/pharmacokinetics; Piperidines/pharmacology; Rats; Spiro Compounds/pharmacokinetics; Spiro Compounds/pharmacology; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Spiro Compounds / Benzopyrans / Receptors, Histamine H3 / Histamine Antagonists Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Type: Article Affiliation country: United States

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