Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice.

Ghazi-Noori, Shabnam; Froud, Kristina E; Mizielinska, Sarah; Powell, Caroline; Smidak, Michelle; Fernandez de Marco, Mar; O'Malley, Catherine; Farmer, Michael; Parkinson, Nick; Fisher, Elizabeth M C; Asante, Emmanuel A; Brandner, Sebastian; Collinge, John; Isaacs, Adrian M

Ghazi-Noori, Shabnam; Froud, Kristina E; Mizielinska, Sarah; Powell, Caroline; Smidak, Michelle; Fernandez de Marco, Mar; O'Malley, Catherine; Farmer, Michael; Parkinson, Nick; Fisher, Elizabeth M C; Asante, Emmanuel A; Brandner, Sebastian; Collinge, John; Isaacs, Adrian M.

Affiliation

Ghazi-Noori S; MRC Prion Unit, UCL Institute of Neurology, London WC1N 3BG, UK.

Brain ; 135(Pt 3): 819-32, 2012 Mar.

Article in En | MEDLINE | ID: mdl-22366797

Subject(s)

Axons/pathology; Endosomal Sorting Complexes Required for Transport/genetics; Inclusion Bodies/pathology; Nerve Degeneration/pathology; Neurons/pathology; Aging/physiology; Animals; Blotting, Western; Frontotemporal Dementia/pathology; Gliosis/pathology; Humans; Immunohistochemistry; Introns/genetics; Kaplan-Meier Estimate; Mice; Mice, Knockout; Mice, Transgenic; Microscopy, Electron; RNA/biosynthesis; RNA/genetics; Real-Time Polymerase Chain Reaction; Survival Analysis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Axons / Inclusion Bodies / Endosomal Sorting Complexes Required for Transport / Nerve Degeneration / Neurons Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Brain Year: 2012 Type: Article Affiliation country: United kingdom

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