Dibenzocyclooctadiene lignans from Kadsura coccinea.
J Asian Nat Prod Res
; 14(4): 364-9, 2012.
Article
in En
| MEDLINE
| ID: mdl-22375875
ABSTRACT
In vitro anti-allergic screening of medicinal herbal extracts revealed that the EtOAc extract of the rhizoma of Kadsura coccinea inhibited nitric oxide (NO) production in a lipopolysaccharide and recombinant mouse interferon-γ activated murine macrophage-like cell line, RAW264.7. Further fractionation of the EtOAc extract led to the isolation of two new dibenzocyclooctadiene lignans kadsuralignan G (1) and kadsuralignan L (2), and three known analog compounds. The absolute stereostructures were established by circular dichroism spectra. Both 1 and 2 showed moderate NO production inhibitory activities.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lignans
/
Anti-Allergic Agents
/
Kadsura
/
Cyclooctanes
Limits:
Animals
Language:
En
Journal:
J Asian Nat Prod Res
Journal subject:
BOTANICA
/
QUIMICA
Year:
2012
Type:
Article
Affiliation country:
China