Eptifibatide-induced thrombocytopenia: with thrombosis and disseminated intravascular coagulation immediately after left main coronary artery percutaneous coronary angioplasty.
Tex Heart Inst J
; 39(1): 86-91, 2012.
Article
in En
| MEDLINE
| ID: mdl-22412237
ABSTRACT
Early clinical trials of eptifibatide did not show a significant association between eptifibatide and the development of thrombocytopenia, thrombosis, or disseminated intravascular coagulation. However, more recent literature has suggested a significant association between eptifibatide and the development of thrombocytopenia and thrombosis. Although the true incidence and the pathophysiology of these associations are unknown, the development of these events can be life-threatening. Herein, we describe the case of a patient who experienced acute onset of profound thrombocytopenia, developing thrombosis, pulmonary emboli, and disseminated intravascular coagulation. This paper adds to the few previous reports of cases that suggested an association between thrombocytopenia, thrombosis, and the administration of eptifibatide. To the best of our knowledge, this is the first case report in the medical literature that associates the new onset of thrombocytopenia, thrombosis, and disseminated intravascular coagulation with the administration of eptifibatide. We also provide a subject review.
Key words
Disseminated intravascular coagulation/diagnosis/etiology/therapy; eptifibatide; percutaneous coronary angioplasty; platelet aggregation inhibitors/adverse effects; platelet glycoprotein GPIIb-IIIa complex/antagonists & inhibitors; thrombocytopenia/chemically induced/prevention & control/therapy; thrombosis/chemically induced
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptides
/
Thrombocytopenia
/
Thrombosis
/
Platelet Aggregation Inhibitors
/
Angioplasty, Balloon, Coronary
/
Coronary Artery Bypass
/
Disseminated Intravascular Coagulation
/
Graft Occlusion, Vascular
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
Limits:
Aged
/
Humans
/
Male
Language:
En
Journal:
Tex Heart Inst J
Year:
2012
Type:
Article
Affiliation country:
United States