NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy.

Schenk, Mirjam; Krutzik, Stephan R; Sieling, Peter A; Lee, Delphine J; Teles, Rosane M B; Ochoa, Maria Teresa; Komisopoulou, Evangelia; Sarno, Euzenir N; Rea, Thomas H; Graeber, Thomas G; Kim, Soohyun; Cheng, Genhong; Modlin, Robert L

Schenk, Mirjam; Krutzik, Stephan R; Sieling, Peter A; Lee, Delphine J; Teles, Rosane M B; Ochoa, Maria Teresa; Komisopoulou, Evangelia; Sarno, Euzenir N; Rea, Thomas H; Graeber, Thomas G; Kim, Soohyun; Cheng, Genhong; Modlin, Robert L.

Affiliation

Schenk M; Department of Medicine, Division of Dermatology, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, California, USA.

Nat Med ; 18(4): 555-63, 2012 Mar 25.

Article in En | MEDLINE | ID: mdl-22447076

Subject(s)

Dendritic Cells/metabolism; Interleukins/metabolism; Leprosy/pathology; Nod2 Signaling Adaptor Protein/metabolism; Antigens, CD; CD11b Antigen; Cell Differentiation/drug effects; Cytokines/genetics; Cytokines/metabolism; Dendritic Cells/drug effects; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Gene Expression Profiling; Gene Expression Regulation/physiology; Granulocyte-Macrophage Colony-Stimulating Factor/genetics; Granulocyte-Macrophage Colony-Stimulating Factor/metabolism; Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology; Humans; Interleukins/pharmacology; Ligands; Macrophage Migration-Inhibitory Factors/metabolism; Oligonucleotide Array Sequence Analysis; Principal Component Analysis; RNA, Messenger/metabolism; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/genetics; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dendritic Cells / Interleukins / Nod2 Signaling Adaptor Protein / Leprosy Limits: Humans Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2012 Type: Article Affiliation country: United States

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