Overexpression of phospholipase D enhances Bcl-2 expression by activating STAT3 through independent activation of ERK and p38MAPK in HeLa cells.

Choi, Hye-Jin; Han, Joong-Soo

Choi, Hye-Jin; Han, Joong-Soo.

Affiliation

Choi HJ; Department of Biochemistry and Molecular Biology, College of Medicine, Hanyang University, Seoul, Republic of Korea.

Biochim Biophys Acta ; 1823(6): 1082-91, 2012 Jun.

Article in En | MEDLINE | ID: mdl-22504301

Subject(s)

Extracellular Signal-Regulated MAP Kinases/metabolism; Phospholipase D/metabolism; Proto-Oncogene Proteins c-bcl-2/metabolism; STAT3 Transcription Factor/metabolism; p38 Mitogen-Activated Protein Kinases/metabolism; Enzyme Activation/drug effects; Gene Knockdown Techniques; HeLa Cells; Humans; MAP Kinase Signaling System/drug effects; Models, Biological; Phosphatidic Acids/metabolism; Phosphatidic Acids/pharmacology; Phospholipases A2/metabolism; Up-Regulation/drug effects; rac1 GTP-Binding Protein/metabolism; rho-Associated Kinases/metabolism; rhoA GTP-Binding Protein/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phospholipase D / Proto-Oncogene Proteins c-bcl-2 / Extracellular Signal-Regulated MAP Kinases / P38 Mitogen-Activated Protein Kinases / STAT3 Transcription Factor Type of study: Prognostic_studies Limits: Humans Language: En Journal: Biochim Biophys Acta Year: 2012 Type: Article

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