Double negative Treg cells promote nonmyeloablative bone marrow chimerism by inducing T-cell clonal deletion and suppressing NK cell function.

Su, Ye; Huang, Xuyan; Wang, Shuang; Min, Wei-Ping; Yin, Ziqin; Jevnikar, Anthony M; Zhang, Zhu-Xu

Su, Ye; Huang, Xuyan; Wang, Shuang; Min, Wei-Ping; Yin, Ziqin; Jevnikar, Anthony M; Zhang, Zhu-Xu.

Affiliation

Su Y; The Multi-Organ Transplant Program, London Health Sciences Centre, London, Ontario, Canada.

Eur J Immunol ; 42(5): 1216-25, 2012 May.

Article in En | MEDLINE | ID: mdl-22539294

Subject(s)

CD4-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/immunology; Chimerism/drug effects; Clonal Deletion/immunology; Killer Cells, Natural/immunology; T-Lymphocytes, Regulatory/immunology; Adoptive Transfer; Animals; Bone Marrow Transplantation/immunology; CD4-Positive T-Lymphocytes/drug effects; CD8-Positive T-Lymphocytes/drug effects; Clonal Deletion/drug effects; Cyclophosphamide/therapeutic use; Graft vs Host Disease/drug therapy; Graft vs Host Disease/immunology; Immunosuppressive Agents/therapeutic use; Killer Cells, Natural/drug effects; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Perforin/immunology; Receptors, Antigen, T-Cell/immunology; Skin Transplantation/immunology; T-Lymphocytes, Regulatory/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Killer Cells, Natural / CD4-Positive T-Lymphocytes / T-Lymphocytes, Regulatory / Clonal Deletion / CD8-Positive T-Lymphocytes / Chimerism Limits: Animals Language: En Journal: Eur J Immunol Year: 2012 Type: Article Affiliation country: Canada

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