Isonicotinamide enhances Sir2 protein-mediated silencing and longevity in yeast by raising intracellular NAD+ concentration.

McClure, Julie M; Wierman, Margaret B; Maqani, Nazif; Smith, Jeffrey S

McClure, Julie M; Wierman, Margaret B; Maqani, Nazif; Smith, Jeffrey S.

Affiliation

McClure JM; Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA.

J Biol Chem ; 287(25): 20957-66, 2012 Jun 15.

Article in En | MEDLINE | ID: mdl-22539348

Subject(s)

Gene Silencing/drug effects; NAD/metabolism; Niacinamide/pharmacology; Nicotinamidase/metabolism; Saccharomyces cerevisiae Proteins/metabolism; Saccharomyces cerevisiae/enzymology; Silent Information Regulator Proteins, Saccharomyces cerevisiae/metabolism; Sirtuin 2/metabolism; DNA, Fungal/genetics; DNA, Fungal/metabolism; DNA, Ribosomal/genetics; DNA, Ribosomal/metabolism; Gene Silencing/physiology; Genetic Loci/physiology; NAD/genetics; Niacinamide/metabolism; Nicotinamidase/genetics; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae Proteins/genetics; Silent Information Regulator Proteins, Saccharomyces cerevisiae/genetics; Sirtuin 2/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Saccharomyces cerevisiae / Niacinamide / Gene Silencing / Saccharomyces cerevisiae Proteins / Silent Information Regulator Proteins, Saccharomyces cerevisiae / Sirtuin 2 / NAD / Nicotinamidase Language: En Journal: J Biol Chem Year: 2012 Type: Article Affiliation country: United States

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