Anti-carcinoembryonic antigen single-chain variable fragment antibody variants bind mouse and human neonatal Fc receptor with different affinities that reveal distinct cross-species differences in serum half-life.

Andersen, Jan Terje; Foss, Stian; Kenanova, Vania E; Olafsen, Tove; Leikfoss, Ingvild S; Roopenian, Derry C; Wu, Anna M; Sandlie, Inger

Andersen, Jan Terje; Foss, Stian; Kenanova, Vania E; Olafsen, Tove; Leikfoss, Ingvild S; Roopenian, Derry C; Wu, Anna M; Sandlie, Inger.

Affiliation

Andersen JT; Centre for Immune Regulation and Department of Molecular Biosciences, University of Oslo, N-0316 Oslo, Norway. j.t.andersen@imbv.uio.no

J Biol Chem ; 287(27): 22927-37, 2012 Jun 29.

Article in En | MEDLINE | ID: mdl-22570488

Subject(s)

Carcinoembryonic Antigen/immunology; Histocompatibility Antigens Class I/immunology; Immunoglobulin G/immunology; Protein Engineering/methods; Receptors, Fc/immunology; Receptors, IgG/immunology; Single-Chain Antibodies/immunology; Animals; Antibody Specificity; Cross Reactions/immunology; Humans; Hydrogen-Ion Concentration; Immunoglobulin G/blood; Iodine Radioisotopes; Mice; Mice, Inbred BALB C; Mice, Transgenic; Single-Chain Antibodies/pharmacokinetics; Species Specificity

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Receptors, Fc / Histocompatibility Antigens Class I / Protein Engineering / Carcinoembryonic Antigen / Receptors, IgG / Single-Chain Antibodies Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2012 Type: Article Affiliation country: Norway

Fulltext

XML

PubMed Links

Search on Google