Synthetic microRNA cassette dosing: pharmacokinetics, tissue distribution and bioactivity.

Wang, Hongyan; Chiu, Ming; Xie, Zhiliang; Chiu, Michael; Liu, Zhongfa; Chen, Ping; Liu, Shujun; Byrd, John C; Muthusamy, Natarajan; Garzon, Ramiro; Croce, Carlo M; Marcucci, Guido; Chan, Kenneth K

Wang, Hongyan; Chiu, Ming; Xie, Zhiliang; Chiu, Michael; Liu, Zhongfa; Chen, Ping; Liu, Shujun; Byrd, John C; Muthusamy, Natarajan; Garzon, Ramiro; Croce, Carlo M; Marcucci, Guido; Chan, Kenneth K.

Affiliation

Wang H; Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210,United States.

Mol Pharm ; 9(6): 1638-44, 2012 Jun 04.

Article in En | MEDLINE | ID: mdl-22574727

Subject(s)

MicroRNAs/chemical synthesis; MicroRNAs/pharmacokinetics; Animals; Blotting, Western; Brain/metabolism; DNA (Cytosine-5-)-Methyltransferases/genetics; DNA (Cytosine-5-)-Methyltransferases/metabolism; DNA Methyltransferase 3A; Enzyme-Linked Immunosorbent Assay; Lung/metabolism; Male; Mice; Mice, Inbred C57BL; MicroRNAs/chemistry; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2/genetics; Proto-Oncogene Proteins c-bcl-2/metabolism; Reverse Transcriptase Polymerase Chain Reaction; DNA Methyltransferase 3B

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: MicroRNAs Limits: Animals Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2012 Type: Article Affiliation country: United States

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