(Z)-1-aryl-3-arylamino-2-propen-1-ones, highly active stimulators of tubulin polymerization: synthesis, structure-activity relationship (SAR), tubulin polymerization, and cell growth inhibition studies.

Reddy, M V Ramana; Akula, Balaiah; Cosenza, Stephen C; Lee, Clement M; Mallireddigari, Muralidhar R; Pallela, Venkat R; Subbaiah, D R C Venkata; Udofa, Andrew; Reddy, E Premkumar

Reddy, M V Ramana; Akula, Balaiah; Cosenza, Stephen C; Lee, Clement M; Mallireddigari, Muralidhar R; Pallela, Venkat R; Subbaiah, D R C Venkata; Udofa, Andrew; Reddy, E Premkumar.

Affiliation

Reddy MV; Department of Oncological Sciences, Mount Sinai School of Medicine, Icahn Medical Institute, 1425 Madison Avenue, New York, New York 10029-6514, United States. r.reddy@mssm.edu

J Med Chem ; 55(11): 5174-87, 2012 Jun 14.

Article in En | MEDLINE | ID: mdl-22587519

Subject(s)

Alkenes/chemical synthesis; Aminophenols/chemical synthesis; Antineoplastic Agents/chemical synthesis; Tubulin Modulators/chemical synthesis; Tubulin/metabolism; Alkenes/chemistry; Alkenes/pharmacology; Aminophenols/chemistry; Aminophenols/pharmacology; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Cell Division/drug effects; Cell Line, Tumor; Cell Proliferation/drug effects; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; G2 Phase/drug effects; Humans; Microtubules/drug effects; Microtubules/ultrastructure; Polymerization; Spindle Apparatus/drug effects; Spindle Apparatus/ultrastructure; Stereoisomerism; Structure-Activity Relationship; Tubulin Modulators/chemistry; Tubulin Modulators/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tubulin / Alkenes / Tubulin Modulators / Aminophenols / Antineoplastic Agents Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2012 Type: Article Affiliation country: United States

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