Pharmacological characterization of abediterol, a novel inhaled ß(2)-adrenoceptor agonist with long duration of action and a favorable safety profile in preclinical models.

Aparici, Mònica; Gómez-Angelats, Mireia; Vilella, Dolors; Otal, Raquel; Carcasona, Carla; Viñals, Marisa; Ramos, Israel; Gavaldà, Amadeu; De Alba, Jorge; Gras, Jordi; Cortijo, Julio; Morcillo, Esteban; Puig, Carlos; Ryder, Hamish; Beleta, Jorge; Miralpeix, Montserrat

Aparici, Mònica; Gómez-Angelats, Mireia; Vilella, Dolors; Otal, Raquel; Carcasona, Carla; Viñals, Marisa; Ramos, Israel; Gavaldà, Amadeu; De Alba, Jorge; Gras, Jordi; Cortijo, Julio; Morcillo, Esteban; Puig, Carlos; Ryder, Hamish; Beleta, Jorge; Miralpeix, Montserrat.

Affiliation

Aparici M; Almirall R&D Center, Sant Feliu de Llobregat, Barcelona, Spain. monica.aparici@almirall.com

J Pharmacol Exp Ther ; 342(2): 497-509, 2012 Aug.

Article in En | MEDLINE | ID: mdl-22588259

Subject(s)

Adrenergic beta-2 Receptor Agonists/pharmacology; Bronchodilator Agents/pharmacology; Receptors, Adrenergic, beta-2/metabolism; Albuterol/analogs & derivatives; Albuterol/pharmacology; Animals; Asthma/drug therapy; Asthma/metabolism; Bronchi/drug effects; Bronchi/metabolism; Bronchoconstriction/drug effects; Dogs; Dose-Response Relationship, Drug; Ethanolamines/pharmacology; Formoterol Fumarate; Guinea Pigs; Humans; Male; Monocytes/drug effects; Monocytes/pathology; Quinolones/pharmacology; Salmeterol Xinafoate

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bronchodilator Agents / Receptors, Adrenergic, beta-2 / Adrenergic beta-2 Receptor Agonists Limits: Animals / Humans / Male Language: En Journal: J Pharmacol Exp Ther Year: 2012 Type: Article Affiliation country: Spain

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