Danthron triggers ROS and mitochondria-mediated apoptotic death in C6 rat glioma cells through caspase cascades, apoptosis-inducing factor and endonuclease G multiple signaling.

Chiou, Shang-Ming; Chiu, Chiz-Hao; Yang, Su-Tso; Yang, Jai-Sing; Huang, Hui-Ying; Kuo, Chao-Lin; Chen, Po-Yuan; Chung, Jing-Gung

Chiou, Shang-Ming; Chiu, Chiz-Hao; Yang, Su-Tso; Yang, Jai-Sing; Huang, Hui-Ying; Kuo, Chao-Lin; Chen, Po-Yuan; Chung, Jing-Gung.

Affiliation

Chiou SM; Department of Functional Neurosurgery, Gamma Knife Center, China Medical University Hospital, Taichung 404, Taiwan.

Neurochem Res ; 37(8): 1790-800, 2012 Aug.

Article in En | MEDLINE | ID: mdl-22592642

Subject(s)

Anthraquinones/pharmacology; Apoptosis Inducing Factor/physiology; Apoptosis/drug effects; Caspases/metabolism; Glioma/metabolism; Reactive Oxygen Species/metabolism; Acetylcysteine/pharmacology; Animals; Cell Death/drug effects; Cell Line, Tumor; Cytochromes c/metabolism; Endodeoxyribonucleases/physiology; Membrane Potential, Mitochondrial/drug effects; Mitochondria/drug effects; Mitochondria/metabolism; Rats; Signal Transduction/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anthraquinones / Reactive Oxygen Species / Apoptosis / Caspases / Apoptosis Inducing Factor / Glioma Limits: Animals Language: En Journal: Neurochem Res Year: 2012 Type: Article Affiliation country: Taiwan

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