Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanism.

Tobe, Ryuta; Yoo, Min-Hyuk; Fradejas, Noelia; Carlson, Bradley A; Calvo, Soledad; Gladyshev, Vadim N; Hatfield, Dolph L

Tobe, Ryuta; Yoo, Min-Hyuk; Fradejas, Noelia; Carlson, Bradley A; Calvo, Soledad; Gladyshev, Vadim N; Hatfield, Dolph L.

Affiliation

Tobe R; Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA.

Biochem J ; 445(3): 423-30, 2012 Aug 01.

Article in En | MEDLINE | ID: mdl-22594686

Subject(s)

Neoplasms, Experimental/drug therapy; Neoplasms, Experimental/metabolism; Sodium Selenite/pharmacology; Thioredoxin Reductase 1/deficiency; Animals; Anticarcinogenic Agents/pharmacology; Base Sequence; Cell Line, Tumor; Gene Knockdown Techniques; Glutathione/metabolism; Hydrogen Peroxide/pharmacology; Mice; NIH 3T3 Cells; Oxidative Stress/drug effects; RNA, Small Interfering/metabolism; Thioredoxin Reductase 1/antagonists & inhibitors; Thioredoxin Reductase 1/genetics; Thioredoxin Reductase 1/metabolism; Thioredoxins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sodium Selenite / Thioredoxin Reductase 1 / Neoplasms, Experimental Limits: Animals Language: En Journal: Biochem J Year: 2012 Type: Article Affiliation country: United States

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