Antibodies, Monoclonal, Murine-Derived/administration & dosage; Antineoplastic Agents/administration & dosage; Benzazepines/administration & dosage; Cell Cycle Proteins/antagonists & inhibitors; Lymphoma, Large B-Cell, Diffuse/drug therapy; Protein Serine-Threonine Kinases/antagonists & inhibitors; Proto-Oncogene Proteins/antagonists & inhibitors; Thiones/administration & dosage; Administration, Oral; Animals; Antibodies, Monoclonal, Murine-Derived/pharmacology; Antineoplastic Agents/pharmacokinetics; Antineoplastic Agents/pharmacology; Benzazepines/pharmacokinetics; Benzazepines/pharmacology; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; Cell Line, Tumor; Cell Survival/drug effects; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Female; Gene Knockdown Techniques; Histones/metabolism; Mice; Mice, Inbred NOD; Mice, SCID; Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; RNA Interference; Rituximab; Thiones/pharmacokinetics; Thiones/pharmacology; Tumor Burden/drug effects; Xenograft Model Antitumor Assays; Polo-Like Kinase 1