Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation.

Jain, Mohit; Nilsson, Roland; Sharma, Sonia; Madhusudhan, Nikhil; Kitami, Toshimori; Souza, Amanda L; Kafri, Ran; Kirschner, Marc W; Clish, Clary B; Mootha, Vamsi K

Jain, Mohit; Nilsson, Roland; Sharma, Sonia; Madhusudhan, Nikhil; Kitami, Toshimori; Souza, Amanda L; Kafri, Ran; Kirschner, Marc W; Clish, Clary B; Mootha, Vamsi K.

Affiliation

Jain M; Broad Institute, Cambridge, MA 02142, USA.

Science ; 336(6084): 1040-4, 2012 May 25.

Article in En | MEDLINE | ID: mdl-22628656

Subject(s)

Cell Proliferation; Glycine/metabolism; Neoplasms/metabolism; Neoplasms/pathology; Breast Neoplasms/genetics; Breast Neoplasms/metabolism; Breast Neoplasms/pathology; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromatography, Liquid; Culture Media; Gene Expression; Gene Expression Profiling; Glycine/biosynthesis; Humans; Metabolic Networks and Pathways/genetics; Metabolome; Mitochondria/enzymology; Mitochondria/metabolism; Neoplasms/genetics; Purines/biosynthesis; Tandem Mass Spectrometry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Proliferation / Glycine / Neoplasms Limits: Humans Language: En Journal: Science Year: 2012 Type: Article Affiliation country: United States

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